Aaryan Senthilvanan
Three research papers accepted at three international conferences in three countries. Presenting at ISMB in Washington DC, ACM-BCB in Italy, and IWBBIO in Spain — work spanning protein interactomics, GPCR signaling, and epigenetic cancer therapeutics.
Where Aaryan Started
His Background
- • Research experience at Stanford and Caltech
- • Deep interest in computational pharmacology and molecular modeling
- • Designed a novel drug candidate for Tardive Dyskinesia using AI-augmented molecular modeling
- • Strong foundation in AI/ML and computational biology
- • Driven to push the boundaries of what high school researchers can achieve
His Goals
- • Publish multiple peer-reviewed research papers
- • Present at top-tier international conferences
- • Advance computational biology and drug discovery
- • Build a research profile competitive for top universities
- • Tackle unsolved problems in protein science and cancer therapeutics
The Problems He Wanted to Solve
Aaryan didn't want to publish one paper. He wanted to tackle three distinct, unsolved problems in computational biology: simulating the human interactome with equivariant graph neural networks, mapping the complete GPCR signaling connectome to deorphanize receptor agonism, and designing a novel epigenetic reprogramming system for cancer cells using phase-state coacervate nanocarriers. Each one became a separate research project, and each one was accepted at a top international conference.
The Research
Aaryan produced three distinct research projects, each addressing a major open problem in computational biology and drug discovery. All three were accepted at top-tier international conferences.
Towards Lighting the Dark Proteome with InteractionFormer: SE(3) Equivariant GNN + ANM to Simulate the Human Interactome
The "dark proteome" — proteins with unknown functions and interactions — remains one of the biggest unsolved challenges in biology
SE(3) equivariant graph neural networks combined with anisotropic network models to simulate protein-protein interactions at scale
GPCRome: The Complete Human GPCR Signaling Connectome to Deorphanize GPCR Agonism
G protein-coupled receptors are the largest receptor family in the human genome, yet many remain "orphan" receptors with unknown ligands
Comprehensive computational mapping of the entire human GPCR signaling network to identify and predict agonist interactions for orphan receptors
ORACLE: Epigenetic Reprogramming of Oncogenically Linked Cells with Novel Phase-State Coacervate Nanocarrier Delivery System
Cancer cells hijack epigenetic machinery to silence tumor suppressors — existing delivery systems for epigenetic therapies lack precision and bioavailability
Novel phase-state coacervate nanocarrier system designed to deliver epigenetic reprogramming agents directly to oncogenically linked cells
Three Problems. Three Breakthroughs. Three Continents.
What sets Aaryan apart isn't just the volume of output — it's the depth and diversity. Each project tackles a fundamentally different problem in computational biology: protein interactomics, receptor pharmacology, and cancer therapeutics. Each required mastery of different computational techniques — from SE(3) equivariant neural networks to coacervate nanocarrier design. And each was independently peer-reviewed and accepted at a top international conference. This is the kind of research portfolio most PhD students spend years building.
Papers Accepted
Countries
Distinct Fields
The Outcome
Washington DC, USA
Intelligent Systems for Molecular Biology — the flagship conference of computational biology
Italy
ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
Spain
International Work-Conference on Bioinformatics and Biomedical Engineering
Talented researcher with Stanford/Caltech experience and strong computational biology foundations, seeking to publish original work
Three first-author papers accepted at three of the world's top computational biology conferences across three countries
The Bigger Picture
International conferences across Washington DC, Italy, and Spain — presenting alongside PhD researchers and professors
The flagship conference of computational biology — one of the most prestigious venues in the field, alongside ACM and IEEE
Research spanning protein interactomics, receptor pharmacology, and cancer therapeutics — a portfolio most doctoral students spend years building
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