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CASE STUDY · YRI FELLOW

Three papers accepted at three international conferences in three countries

Aaryan produced three distinct research projects, each addressing a different open problem in computational biology. InteractionFormer simulates the human interactome using SE(3) equivariant graph neural networks with anisotropic network models, GPCRome maps the complete human GPCR signaling connectome to deorphanize receptor agonism, and ORACLE designs a phase-state coacervate nanocarrier system for epigenetic reprogramming of cancer cells. All three were independently peer reviewed and accepted, and he presents in Washington DC, Italy and Spain.

FIELDComputational Biology & Drug Discovery
RESULT3 papers accepted at ISMB, ACM-BCB and IWBBIO
VENUEISMB, ACM-BCB, IWBBIO, 2026
Aaryan Senthilvanan
Aaryan Senthilvanan, YRI FellowISMB
BEFORE THE FELLOWSHIP

A high school student with strong computational foundations and no published record, looking for a way to work on real problems in drug discovery.

AFTER

Three first-author papers accepted at three of the world's top computational biology conferences across three countries.

THE LEDGER
01InteractionFormer accepted at ISMB 2026 in Washington DC
02GPCRome accepted at ACM-BCB 2026 in Italy
03ORACLE accepted at IWBBIO 2026 in Spain
04Three first-author papers across three distinct fields of computational biology
05Designed a novel drug candidate for Tardive Dyskinesia using AI-augmented molecular modeling
NEXT CASE STUDYAnsh Kumar, Published at MIT URTC, IEEE accepted, Rashtriya Bal Puraskar nominee

Every case study starts with one application.

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